Where Form 5495 Compensation 2017-2023

Hello my name is DDS tinium directed the Max Planck Institute for research in Bad Nauheim Germany and today this third part we're going to be talking about the phenomenon of genetic compensation in the context of a scary development in the zebrafish embryo historically gene function in zebrafish has been studied initially through a full genetic approach mainly for utilizing the genome introducing mutations randomly and then doing phenotypic screening more recently morpholino zant essentially goes had been used to knockdown gene function and then more recently just a few years ago using zinc finger nucleases as well as talents and Chris Burke has nine technology mutations have been introduced in specific genes to study not only genes that were studied previously using oph lie notes but also other genes and the studies that I'll be telling you about today or essentially inspired by the fact that looking at specific genes that have been studied was using more funny nose as well as reversed genetic techniques it became apparent that in many cases the phenotypes induced by mutations or much milder than those induced by the morpholino technology and so essentially just to give you a little background Mourinho's are as you can see here modifying all egos they're highly stable they bind RNA there used to rock neither translation or splicing and so the question then is why mutant phenotypes are in sight of a milder than Tysons phenotypes so mutant phenotypes versus anti-fans phenotypes I will also be using the word more front for morpholino induced so we'll be talking about mutant versus morph and phenotype and mutants often refer to as knockouts and anti sensors knockdowns so let's understand by some history of the anti sense approach anti sense technology and more than thirty years ago...